City’s goal difference stands at plus 46, five better than Liverpool’s, having scored 66 goals prior to the game at Goodison Park.
Guardiola said: “The first message is to win the game and the second one is; if you can score, score and if you can avoid conceding, do it because maybe you could win the Premier League on goal difference.
“While we are not going to say to the guys today we have to win 25-zero – I never say that – first you have to win the game and then second try, because it can happen.
“I’m pretty sure the winner will be the last fixture or the last two. I’m sure of that.”
City have been reinstalled as title favourites by bookmakers following Liverpool’s wobbles in the past week. Jurgen Klopp’s men have looked nervous in successive 1-1 draws against Leicester and West Ham.